Material Request
The Resource for Molecular Imaging Agents in Precision Medicine offers a variety of resources and materials available for researchers to utilize. Information about available materials and how to request them can be found below. In addition to those items below, please feel free to request other materials that are generated by the Research projects of this National Center for Biomedical Imaging and Bioengineering through the “Contact Us” tab.
PC3 PIP
PSMA-positive prostate cancer cell line.
Shipping & Processing Fee: $300 per line
References:
A PSMA-Targeted Theranostic Agent for Photodynamic Therapy.
Chen Y, et al. J Photochem Photobiol B 2018.
PMID 28063300
Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.
Nimmagadda S, et al. J Nucl Med 2018.
PMID 29025989
PC3 flu
PSMA-negative prostate cancer cell line.
Shipping & Processing Fee: $300 per line
References:
A PSMA-Targeted Theranostic Agent for Photodynamic Therapy.
Chen Y, et al. J Photochem Photobiol B 2018.
PMID 28063300
Low-Level Endogenous PSMA Expression in Nonprostatic Tumor Xenografts Is Sufficient for In Vivo Tumor Targeting and Imaging.
Nimmagadda S, et al. J Nucl Med 2018.
PMID 29025989
ow letters, that works well on almost every site.
CHO-hPD-L1
CHO cell line stably expressing human PD-L1.
Shipping & Processing Fee: $300 per line
References:
PD-L1 Detection in Tumors Using [(64)Cu]Atezolizumab with PET.
Lesniak WG, et al. Bioconjug Chem 2016. Among authors: Nimmagadda S. PMID 27458027 Free PMC article.
Rapid PD-L1 detection in tumors with PET using a highly specific peptide.
Chatterjee S, et al. Biochem Biophys Res Commun 2017. Among authors: Nimmagadda S. PMID 28025143 Free PMC article.
Peptide-Based (68)Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer.
De Silva RA, et al. Mol Pharm 2018. Among authors: Nimmagadda S. PMID 30037229 Free PMC article.
Peptide-based PET quantifies target engagement of PD-L1 therapeutics.
Kumar D, et al. J Clin Invest 2019. Among authors: Nimmagadda S. PMID 30457978 Free PMC article.
A humanized antibody for imaging immune checkpoint ligand PD-L1 expression in tumors.
Chatterjee S, et al. Oncotarget 2016. Among authors: Nimmagadda S. PMID 26848870 Free PMC article.
Olsa-RVRR
Olsalazine (Olsa, green) is an aspirin/salicylic acid) analogue that acts as a cancer theranostic: it is a broad spectrum anti-cancer agent (DNA methylation inhibitor) that can be detected with CEST MRI at 9.8 ppm. The conjugated RVRR is a substrate for the tumor-overexpressed enzyme furin. The compound Olsa-RVRR is available with or without conjugation to a CBT group (pink) for intracellular self-assembly of Olsa-RVRR nanoparticles in tumor cells. Compounds with specificities for other tumor enzymes (i.e., legumain) will be available soon.
Shipping & Processing Fee: To Be Determined
References:
Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy.
Yuan Y et al. Nat Mater. 2019. Among authors: Bulte JWM. PMID: 31636420
Furin-Mediated Self-Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors.
Yuan Y et al. Angew Chem Int Ed Engl. 2021. Among authors: Bulte JWM. PMID: 33325142
SPIO-labeled MSC-EVs
SPIO-labeled MSC-EVs for use as immunomodulatory bimodal MRI contrast agents and MPI tracers.
Shipping & Processing Fee: To Be Determined
References:
Highly efficient magnetic labeling allows MRI tracking of the homing of stem cell-derived extracellular vesicles following systemic delivery.
Han Z et al. J Extracell. Vesicles. 2021.
Unlabeled, mannose-rich MSC-EVs
Unlabeled, mannose-rich MSC-EVs for use as immunomodulatory MRI diaCEST contrast agents.
Shipping & Processing Fee: To Be Determined
References:
In vivo tracking of unlabeled mesenchymal stromal cells by mannose-weighted chemical exchange saturation transfer MRI.
Yuan Y et al. Nat Biomed. 2022.
FNDP PET Precursor
Shipping & Processing Fee: To Be Determined
References:
First-in-human use of 11C-CPPC with positron emission tomography for imaging that macrophage
Shipping & Processing Fee: To Be Determined
References:
First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET.
Coughlin JM et al. Eur J Nucl Med Mol Imaging. 2021.
colony stimulating factor 1 receptor.
Coughlin JM et al. EJNMMI. in press.
CSF1R PET Precursor
Shipping & Processing Fee: To Be Determined
References:
Shipping & Processing Fee: To Be Determined
References:
PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R).
Horti AG et al. Proc Natl Acad Sci USA. 2019
Coughlin JM et al. EJNMMI. in press.